Keywords
Escherichia coli
Drug resistance
Antibiotic
Fosfomycin
How to Cite
Abstract
Fosfomycin is a broad-spectrum antimicrobial whose mechanism of action is based on the inhibition of peptidoglycan synthesis, leading to bacterial lysis. It is used to treat urinary tract infections in adults and children over 6 years old and offers advantages such as easy dosing and few adverse effects. However, there is a lack of studies on its efficacy and safety in children, which motivated this review to evaluate its pediatric use in UTIs. Therefore, this work aims to analyze the current scientific literature on the characteristics of fosfomycin and its effectiveness in treating minors, as well as drug resistance within its antibiotic class. This study is an integrative literature review that gathered updated information on UTIs from international and national publications in English, Portuguese, and Spanish, in the form of articles published in the MEDLINE, LILACS, and PUBMED databases, found through searches conducted with Health Sciences Descriptors (DeCS/MeSH). In this way, it was possible to synthesize the main factors to consider in the use of fosfomycin for treating UTIs in the pediatric population, with its unique mechanism of action providing a specific mode of activity. Its use has shown positive results in treating urinary tract infections. It was concluded that fosfomycin is well tolerated and associated with favorable treatment outcomes in children with UTIs. As resistance to commonly used antibiotics is increasing, treatment should be carefully guided.
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