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Abstract
This study aimed to detail the clinical and epidemiological aspects of leptospirosis, aiming to contribute to effective strategies to combat the disease in public health. An Integrative Literature Review was carried out, with a systematic search in PUBMED and the VHL, using the Health Sciences Descriptors in English "Clinical Epidemiology", "Disease Management" and "Leptospirosis", combined by the Boolean operator AND. The results highlighted the crucial need to improve infrastructure and implement appropriate sanitary measures, as well as emphasizing the importance of effective rodent control through multidisciplinary approaches. It was observed that leptospirosis has two distinct phases, immunological and leptospiremic, requiring comprehensive treatment with antibiotic therapy, particularly doxycycline, together with the use of probiotics and, in some cases, corticosteroids. It is concluded that the effective approach to leptospirosis depends on robust preventive measures and collaboration between different professional areas, including medical and veterinary support, essential for the success in preventing and treating this significant zoonotic disease.
References
AJJIMARUNGSI, Atta et al. Clinical characteristics, outcomes, and predictors of leptospirosis in patients admitted to the medical intensive care unit: A retrospective analysis. Journal of infection and public health, v. 13, n. 12, p. 2055-2061, 2020.
ALLYN, Jérôme et al. Severe leptospirosis in tropical and non-tropical areas: A comparison of two french, multicentre, retrospective cohorts. PLOS Neglected Tropical Diseases, v. 18, n. 4, p. e0012084, 2024.
CEDANO, Jorge et al. Clinical characterization of patients with severe leptospirosis in a tertiary hospital in Cali, Colombia, 2010-2016. Biomédica, v. 39, p. 108-116, 2019.
CHARLES, James C.; JAYARAJAH, Umesh; SUBASINGHE, Duminda. Clinical characteristics and outcomes of patients with leptospirosis complicated with acute pancreatitis: a systematic review. Journal of International Medical Research, v. 51, n. 9, p. 03000605231197461, 2023.
CHOMEL, B. B. Zoonoses. Reference Module in Biomedical Sciences, 2014.
CREMONESE, Cleber et al. Simplified sewerage to prevent urban leptospirosis transmission: A cluster non-randomised controlled trial protocol in disadvantaged urban communities of Salvador, Brazil. BMJ open, v. 13, n. 6, p. e065009, 2023.
DOUINE, Maylis et al. Zoonoses and gold mining: A cross-sectional study to assess yellow fever immunization, Q fever, leptospirosis and leishmaniasis among the population working on illegal mining camps in French Guiana. PLOS Neglected Tropical Diseases, v. 16, n. 8, p. e0010326, 2022.
FRANCEY, Thierry et al. Evaluation of changes in the epidemiology of leptospirosis in dogs after introduction of a quadrivalent antileptospiral vaccine in a highly endemic area. Journal of veterinary internal medicine, v. 34, n. 6, p. 2405-2417, 2020.
GOMES, Luís Gustavo Oliveira et al. Zoonoses: as doenças transmitidas por animais. Revista Brasileira Multidisciplinar, v. 25, n. 2, p. 158-174, 2022.
GUILLAMET, Laia J. Vazquez et al. Leptospirosis: epidemiological and clinical characteristics at the national reference hospital in Panama. The American Journal of Tropical Medicine and Hygiene, v. 107, n. 6, p. 1261, 2022.
ISMAIL, Zuhair B. et al. Seroprevalence and risk factors of Leptospira serovar Pomona and Leptospira serovar Hardjo infection in dairy cows in Jordan. The Journal of Infection in Developing Countries, v. 13, n. 06, p. 473-479, 2019.
MAZZOTTA, Elisa et al. Are small animal practitioners occupationally exposed to leptospirosis? Results of a serological survey. International Journal of Environmental Research and Public Health, v. 19, n. 3, p. 1797, 2022.
PETAKH, Pavlo et al. Current treatment options for leptospirosis: a mini-review. Frontiers in Microbiology, v. 15, p. 1403765, 2024.
RAJAPAKSE, Senaka. Leptospirosis: clinical aspects. Clinical Medicine, v. 22, n. 1, p. 14-17, 2022.
SYKES, Jane E. et al. Role of diagnostics in epidemiology, management, surveillance, and control of leptospirosis. Pathogens, v. 11, n. 4, p. 395, 2022.
YANG, Bada et al. Nucleic acid and antigen detection tests for leptospirosis. Cochrane Database of Systematic Reviews, n. 8, 2019.
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