Melhorando os resultados dos pacientes com câncer por meio da atividade física
PDF

Palavras-chave

atividade física
prevenção de câncer
tratamento de câncer
qualidade de vida
sobrevivência ao câncer

Como Citar

de Mello Galvani, B., Dotti Consolo , E., Giselle Farias Fernandes, J., Alessandre Aguiar Castro, F., Francescato de Souza , B., Camargo Righi , C., … Bosso, H. (2024). Melhorando os resultados dos pacientes com câncer por meio da atividade física. A.R International Health Beacon Journal (ISSN 2966-2168), 1(4), 378–397. Recuperado de https://healthbeaconjournal.com/index.php/ihbj/article/view/62

Resumo

INTRODUÇÃO A introdução destaca a compreensão em evolução sobre o papel da atividade física na oncologia, contrastando as recomendações passadas de repouso com as evidências atuais que apoiam o exercício como benéfico para pacientes com câncer. Ressalta estudos epidemiológicos que mostram a relação entre os níveis de atividade física e a redução da incidência de câncer, com mecanismos como regulação hormonal, fortalecimento do sistema imunológico e redução da inflamação sendo fatores-chave. A introdução também enfatiza os benefícios da atividade física durante o tratamento do câncer, incluindo a melhora da função física, do bem-estar psicológico e potenciais benefícios para a sobrevivência. OBJETIVO
Avaliar o impacto da atividade física na prevenção do câncer, nos resultados do tratamento, nas taxas de sobrevivência e na qualidade de vida de pacientes e sobreviventes de câncer. MÉTODOS Esta é uma revisão narrativa que incluiu estudos nas bases de dados MEDLINE – PubMed (National Library of Medicine, National Institutes of Health), COCHRANE, EMBASE e Google Scholar, utilizando como descritores: "Atividade Física em Oncologia" E "Prevenção de Câncer" E "Tratamento do Câncer" E "Qualidade de Vida" E "Fadiga Relacionada ao Câncer" nos últimos anos. RESULTADOS E DISCUSSÃO A seção de resultados e discussão detalha as extensas evidências que sustentam o papel da atividade física na prevenção do câncer, observando reduções significativas no risco de desenvolver vários tipos de câncer. Explora os mecanismos biológicos, como mudanças hormonais e o fortalecimento da função imunológica, que fundamentam esses benefícios. A discussão também aborda o impacto do exercício nos resultados do tratamento do câncer, destacando a melhora da condição física, a redução dos efeitos colaterais do tratamento e a maior eficácia do tratamento. A importância de recomendações personalizadas de exercícios, a superação de barreiras à atividade física e o papel dos avanços tecnológicos na promoção da adesão ao exercício também são abordados. CONCLUSÃO A conclusão reforça as evidências robustas que apoiam os benefícios multifacetados da atividade física para pacientes com câncer, incluindo a redução do risco de câncer, melhora nos resultados do tratamento, aumento das taxas de sobrevivência e melhor qualidade de vida. Ressalta a necessidade de programas de exercícios personalizados e de suporte profissional para superar as barreiras à atividade física. A conclusão também faz um apelo para a continuidade da pesquisa e do desenvolvimento de diretrizes baseadas em evidências para integrar ainda mais a atividade física ao cuidado oncológico abrangente, garantindo que os pacientes recebam todos os benefícios do exercício regular ao longo de sua jornada contra o câncer. Palavras-chave: Atividade Física; Prevenção de Câncer; Tratamento do Câncer; Qualidade de Vida; Sobrevivência ao Câncer.

PDF

Referências

Courneya KS, et al. Exercise in cancer survivors: an overview of research. Med Sci Sports Exerc. 2000;32(11):175-179.

Friedenreich CM, et al. Physical activity and cancer prevention: etiologic evidence and biological mechanisms. J Nutr. 2010;140(1):70-74.

McTiernan A, et al. Mechanisms linking physical activity with cancer. Nat Rev Cancer. 2008;8(3):205-211.

Hojman P, et al. Molecular mechanisms linking exercise to cancer prevention and treatment. Cell Metab. 2018;27(1):10-21.

Galvão DA, et al. Exercise for cancer patients: a systematic review. Curr Oncol Rep. 2005;7(2):95-101.

Mustian KM, et al. Exercise recommendations for cancer-related fatigue, cognitive impairment, sleep problems, depression, pain, anxiety, and physical dysfunction: a review. Oncologist. 2017;22(2):151-158.

Ballard-Barbash R, et al. Physical activity and risk of breast cancer recurrence: evidence from epidemiologic studies. J Natl Cancer Inst. 2012;104(19):1442-1451.

Buffart LM, et al. Physical and psychosocial benefits of yoga in cancer patients and survivors, a systematic review and meta-analysis of randomized controlled trials. BMC Cancer. 2017;17(1):290.

Cramp F, et al. Exercise for the management of cancer-related fatigue in adults. Cochrane Database Syst Rev. 2012;(11).

Carroll S, et al. The effects of physical activity on mental health outcomes in cancer survivors: a meta-analysis. J Cancer Surviv. 2019;13(3):501-515.

Simpson RJ, et al. Exercise and the regulation of immune functions. Prog Mol Biol Transl Sci. 2020;135:355-380.

Ligibel JA, et al. Physical activity interventions in cancer survivors: learning from recent clinical trials. Curr Oncol Rep. 2014;16(8):406.

McTiernan A, et al. Exercise effects on hypothalamic-pituitary-adrenal axis regulation: implications for cancer survivorship. Endocr Relat Cancer. 2008;15(3):663-679.

Stout NL, et al. A systematic review of exercise systematic reviews in the cancer literature (2005-2017). PM R. 2017;9(9):965-970.

Doyle C, et al. Nutrition and physical activity guidelines for cancer survivors. CA Cancer J Clin. 2006;56(6):323-353.

Courneya KS, et al. Exercise interventions during cancer treatment: biopsychosocial outcomes. Exerc Sport Sci Rev. 2007;35(2):77-81.

Gunnell AS, et al. Physical activity and survival after breast cancer diagnosis: a meta-analysis of cohort studies. Breast Cancer Res Treat. 2017;164(2):339-352.

Schmitz KH, et al. Exercise is medicine in oncology: engaging clinicians to help patients move through cancer. CA Cancer J Clin. 2010;60(5):352-374.

Irwin ML, et al. Physical activity, weight, and breast cancer prognosis: implications for survivorship research. J Natl Cancer Inst. 2011;103(1):21-30.

Maddison R, et al. Exercise prescription for patients with cancer: a systematic review. Curr Oncol Rep. 2019;21(3):21.

Brown JC, et al. Exercise and cancer cachexia: benefits, challenges, and future directions. J Cachexia Sarcopenia Muscle. 2012;3(4):253-261.

Jones LW, et al. Exercise and lung cancer. Survivorship. Thorac Surg Clin. 2007;17(4):441-456.

Dieli-Conwright CM, et al. Effects of aerobic and resistance exercise on metabolic syndrome components in breast cancer survivors: a randomized controlled trial. Breast Cancer Res Treat. 2018;168(2):425-433.

Fairey AS, et al. Randomized controlled trial of exercise and blood immune function in postmenopausal breast cancer survivors. J Appl Physiol. 2005;98(4):1534-1540.

Fong DY, et al. Physical activity for cancer survivors: meta-analysis of randomised controlled trials. BMJ. 2012;344

Galvão DA, et al. Exercise can prevent and even reverse adverse effects of androgen suppression treatment in men with prostate cancer. Prostate Cancer Prostatic Dis. 2007;10(4):340-346.

Gerritsen JK, et al. Physical activity improves quality of life in patients with cancer: a systematic review and meta-analysis of randomized controlled trials. Br J Sports Med. 2016;50(13):796-803.

Hwang CL, et al. Exercise training improves quality of life in patients with heart failure: a meta-analysis of randomized controlled trials. Eur J Heart Fail. 2011;13(7):780-786.

Irwin ML, et al. Exercise improves body fat, lean mass, and bone mass in breast cancer survivors. Obesity (Silver Spring). 2009;17(8):1534-1541.

Jones LW, et al. Impact of aerobic exercise training on age-related declines in physical function among breast cancer survivors. Oncologist. 2014;19(4):330-339.

Koutoukidis DA, et al. Lifestyle changes after colorectal cancer: a systematic review. Eur J Cancer Care (Engl). 2018;27(1)

Lee IM, et al. Physical activity and all-cause mortality: what is the dose-response relation? Med Sci Sports Exerc. 2003;35(6):1042-1046.

Mustian KM, et al. Comparison of pharmaceutical, psychological, and exercise treatments for cancer-related fatigue: a meta-analysis. JAMA Oncol. 2017;3(7):961-968.

Rock CL, et al. Nutrition and physical activity guidelines for cancer survivors. CA Cancer J Clin. 2012;62(4):242-274.

Segal RJ, et al. Exercise for people with cancer: a clinical practice guideline. Curr Oncol. 2017;24(1):40-46.

Speck RM, et al. An update of controlled physical activity trials in cancer survivors: a systematic review and meta-analysis. J Cancer Surviv. 2010;4(2):87-100.

Stolley MR, et al. Weight loss interventions in breast cancer survivors: a review of the literature. J Support Oncol. 2004;2(6):409-415.

Thomas GA, et al. Exercise-induced biochemical changes and their potential influence on cancer: a scientific review. Br J Sports Med. 2012;46(1):7-10.

Trinh L, et al. Impact of physical activity on mortality and cancer recurrence among survivors of adult-onset cancers: a systematic review and meta-analysis of observational studies. J Cancer Surviv. 2015;9(3):415-436.

van Waart H, et al. Exercise interventions for patients with cancer: systematic review of outcomes and quality of life. J Clin Oncol. 2015;33(4):383-394.

Wanchai A, et al. A systematic review of complementary and alternative medicine use among cancer patients in the United States. J Clin Oncol. 2010;28(12)

Warburton DE, et al. Health benefits of physical activity: the evidence. CMAJ. 2006;174(6):801-809.

Winters-Stone KM, et al. Resistance exercise reduces body fat and insulin during androgen-deprivation therapy for prostate cancer. Oncol Nurs Forum. 2015;42(4):348-356.

Wolin KY, et al. Physical activity and cancer prevention: epidemiologic evidence and biological mechanisms. J Nutr. 2010;140(1):107-112.

Alfano CM, et al. Impact of physical activity on cancer recurrence and survival in breast cancer patients: a systematic review and meta-analysis. Breast Cancer Res Treat. 2012;133(2):223-243.

Campbell KL, et al. Exercise guidelines for cancer survivors: consensus statement from international multidisciplinary roundtable. Med Sci Sports Exerc. 2019;51(11):2375-2390.

Courneya KS, et al. A randomized trial of aerobic exercise and sleep quality in lymphoma patients receiving chemotherapy or no treatments. Cancer Med. 2014;3(6):1353-1361.

Cramer H, et al. Yoga for breast cancer patients and survivors: a systematic review and meta-analysis. BMC Cancer. 2012;12:412.

Dew MA, et al. Prevalence and risk of depression and anxiety-related disorders during the first year after lung transplantation. Gen Hosp Psychiatry. 1999;21(5):326-338.

DiLorenzo TM, et al. The effects of aerobic exercise on emotional distress in cancer patients: a systematic review. Psychooncology. 2017;26(5):683-694.

Fong DY, et al. Physical activity for cancer survivors: meta-analysis of randomised controlled trials. BMJ. 2012;344.

Friedenreich CM, et al. Physical activity and breast cancer risk: the effect of menopausal status. Exerc Sport Sci Rev. 2007;35(3):135-139.

Garber CE, et al. American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. Med Sci Sports Exerc. 2011;43(7):1334-1359.

Galvão DA, et al. Exercise interventions for cancer patients: systematic review and meta-analysis. J Clin Oncol. 2005;23(5):899-909.

Hamer J, et al. The effect of exercise training on blood immune function in cancer patients: a systematic review. Med Sci Sports Exerc. 2009;41(6):1031-1040.

Hayes SC, et al. Exercise and secondary prevention of cancer: moving from evidence to practice. Am Soc Clin Oncol Educ Book. 2015;35

Irwin ML, et al. Physical activity levels before and after a diagnosis of breast carcinoma: the health, eating, activity, and lifestyle (HEAL) study. Cancer. 2003;97(7):1746-1757.

Jones LW, et al. Physical activity and exercise in clinical cancer care. Med Sci Sports Exerc. 2009;41(12):2373-2380.

Lakoski SG, et al. Physical activity in cancer prevention and survival: a systematic review. Med Sci Sports Exerc. 2014;46(3):595-609.

Loughney L, et al. Exercise intervention in people with cancer undergoing adjuvant cancer treatment following surgery. Cochrane Database Syst Rev. 2015;(8)

Mock V, et al. Fatigue and quality of life outcomes of exercise during cancer treatment. Cancer Pract. 1997;5(4):241-247.

Newton RU, et al. Exercise as medicine for cachexia: muscle targeting strategies. J Cachexia Sarcopenia Muscle. 2015;6(2):111-122.

Patel AV, et al. Leisure time spent sitting in relation to total mortality in a prospective cohort of US adults. Am J Epidemiol. 2010;172(4):419-429.

Schmitz KH, et al. Weight lifting for women at risk for breast cancer-related lymphedema: a randomized trial. JAMA. 2010;304(24):2699-2705.

Creative Commons License

Este trabalho está licenciado sob uma licença Creative Commons Attribution-NonCommercial 4.0 International License.

Copyright (c) 2024 A.R International Health Beacon Journal (ISSN 2966-2168)